United States Department of Veterans Affairs
United States Department of Veterans Affairs

Center for Imaging of Neurodegenerative Diseases

Norbert Schuff, Ph.D.

Professor of Radiology


Norbert Schuff

Contact

Mailing Address
Center for Imaging of Neurodegenerative Diseases (CIND)
Veterans Affairs Medical Center, 114M
4150 Clement St.
San Francisco, CA 94121

Phone  [415] 221-4810 ext. 4904
Fax  [415] 668-2864
Email Norbert.Schuff@ucsf.edu

Research Program

The overall focus of my research is twofold: a) developing novel methods of quantitative magnetic resonance imaging and b) identifying MRI based markers for better diagnosis, prognosis, and monitoring treatment of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease.

The focus of my technically oriented research is on developing optimized high field 4 Tesla MRI techniques, building on my previous work at 1.5Tesla. In particular, my research is aimed to improve detection of brain perfusion by developing better strategies for arterial spin labeling (ASL), detection of white matter fiber bundles by improving acquisition and evaluation of diffusion tensor imaging (DTI) as well as diffusion spectrum imaging (DSI). Furthermore, I am improving susceptibility–weighted imaging (SWI) to detect brain iron concentrations. Taken together, these various MRI methods provide a powerful multi-modality approach to study neurodegenerative diseases. However, structural ASL, DTI or DSI, and SWI are often analyzed individually, whereas a simultaneous analysis of these multimodal data is expected to provide a much more powerful analysis. I am therefore also exploring statistical methods for a multivariate analysis of MRI data.

The focus of my clinically oriented research aims to establish MRI based biomarkers of various types of neurodegenerative diseases, especially of Parkinson’s disease (PD),  that allow accurate detection of neurological diseases as well as assessment of their progressions and treatment responses. My approach is unique in that it utilizes multimodal measurements to assess various brain alterations, including structural MRI to detect tissue loss, arterial spin labeling (ASL) MRI to measure regional cerebral blood flow, diffusion tensor imaging (DTI) to assess nerve fiber integrity, and susceptibility-weighted imaging (SWI) to measure levels of brain iron.

In summary, my research plan aims to technically improve quantitative medical imaging that clinically leads in turn to better diagnosis, prognosis, and prediction of neurodegenerative diseases.



Education

Undergraduate & Graduate
1975 - 1978 University of Heidelberg, Germany, B.Sc., Physics & Astronomy
1978 - 1981 University of Heidelberg, Germany, M.Sc., Physics & Astronomy
1981 - 1983 University of Heidelberg, Germany, PhD., Physics
Postgraduate Training
1983 - 1984 Institute of Molecular Physics, National Academy of Sciences, Poznan, Poland
Research Assistant
1993 - 1993 UCSF, Radiology
Postdoctoral Fellow


Work Experience

Outside of the University of California School of Medicine
03/84 - 12/89Bruker Medizintechnik, Karlsruhe, GermanyR&D Scientist
01/90 - 06/92Varian NMR Instruments, Palo Alto, USAR&D Scientist
07/92 - 12/92Varian GmbH, Darmstadt, GermanyApplications Physicist
07/94 - presentDVA Medical Center, San FranciscoResearch Scientist
Inside of the University of California School of Medicine
01/94 - 01/96Dept. of RadiologyAssistant Adjunct Professor
02/96 - 07/96Dept. of RadiologyAssistant Research Scientist
08/96 - 06/00Dept. of RadiologyAssistant Adjunct Professor
07/00 - 06/06Dept. of RadiologyAssociate Adjunct Professor
07/06 - presentDept. of RadiologyAdjunct Professor


Selected Bibliography

Patents
  1. D. Ratzel and N. Schuff. A Method to Generate Spin-Echo Pulse Trains using a MR; DE Patent 3730148 C210/22/92/DE.
  2. N. Schuff and E.H. Williams. Reduction of Gradient Coil Interaction with Room Temperature Shims.; US Patent 811442 12/19/91/US
1983 - 1990
  1. Schuff N. and Haeberlen U. 2D Correlation Spectroscopy in Homonuclear Dipolar-Coupled Solids. Journal of Magnetic Resonance, 52, 267-281, (1983).
  2. Schuff N. and Haeberlen U. Rate Constants of Flipping, and Shielding Tensors of Stationary Water Molecules in Potassium Oxalate Monohydrate. Journal of Magnetic Resonance, 62, 406-416, (1985).
  3. Rodiek S., Juretschke H-P., Hoepfel D. and Schuff N. MR Tomographie und Spektroskopie der Skelettmuskulatur bei hohen Magnetfeldstarken (MR Tomography and Spectroscopy of Skeletal Muscles at High Magnetic Fields). RoFo, Fortschritte auf dem Gebiet der Rontgenstrahlung und Nuklearmedizin, 144, 89-94, (1986).
  4. Norris D., Schuff N. and Leibfritz D.. INEPT Enhanced 13C Spectroscopy using Double-tuned Surface Coils. Journal of Magnetic Resonance, 78, 362-366, (1988).
  5. Durst P., Schuff N., Croq M.A., Mokrani M.C. and Macher J.P.. Non-invasive In-vivo Detection of a Fluorinated Neuroleptic in the Human Brain by 19F NMR Spectroscopy. Journal of Psychology Research: Neuroimaging, Vol. 35, No. 2, (1990).
  6. Jehenson P., Westphal M. and Schuff N. Analytical Method for the Compensation of Eddy-Current Effects Induced by Pulsed Magnetic Field Gradients in NMR Systems. Journal of Magnetic Resonance, 90, 264-278, (1990).

1991 - 1995
  1. Bartels M, Gunther U, Albert K, Mann K, Schuff N, Stuckstedte H. 19F nuclear magnetic resonance spectroscopy of neuroleptics: the first in vivo pharmacokinetics of trifluoperazine in the rat brain and the first in vivo spectrum of fluphenazine in the human brain. Biol Psychiatry. 1991;30(7):656-62.
  2. Schuff N., Hornung P.A. and Williams E.H. A Study of Changes in Poly(methyl-methacrylate) PMMA Resulting from the Adsorption of Methanol using NMR Imaging. Proceedings of the Material Research Society,, Vol. 217, 55, (1991).
  3. Hornung P.A. and Schuff N. Non-invasive Imaging and Spectroscopy - Broad Applications using Magnetic Resonance. Clinical Chemistry, Vol. 38 (9), 160, (1992).

1996 - 1999
  1. Haupt C.I., Schuff N., Weiner M.W., and Maudsley A.A. Lipid Removal in 1H Spectroscopic Imaging by Data Extrapolation. Magnetic Resonance in Medicine, 35, 678-687, (1996).
  2. Rooney W.D., Goodkin D.E., Schuff N., Meyerhoff D.J., Norman D., and Weiner M.W.. 1H MRSI of Normal Appearing White Matter in Multiple Sclerosis. Multiple Sclerosis 1997;3:231-37.
  3. Tanabe J. Amend D., Schuff N., Di Sclafani V., Ezekiel F., Norman D, Fein G, Weiner M.W., Tissue Segmentation of the Brain in Alzheimer's Disease. American Journal of Neuroradiology, 18:115-123; 1997.
  4. Ende G., Laxer K., Knowlton R.C., Matson G.B., Schuff N. , Fein G., Weiner M.W. Temporal Lobe Epilepsy: Bilateral Hippocampal Metabolite Changes Revealed at Proton MR Spectroscopic Imaging Radiology, 202 (3), 809-818; 1997.
  5. Schuff N., Marmar C.R., Weiss D.S., Neylan T.C., Schoenfeld F., Fein G., Weiner M.W. Reduced Hippocampal Volume and N-Acetyle Aspartate in Post Traumatic Stress Disorder. The Annals of the New York Academy of Sciences. Vol. 821:516-520; 1997.
  6. Jody L. Tanabe, Frank Ezekiel, William J. Jagust, Norbert Schuff, George Fein. A volumetric method for evaluating magnetization transfer ratio of tissue categories: Application to white matter signal hyperintensities in the elderly. Radiology 1997; 204:570-75.
  7. N. Schuff, D. Amend, F. Ezekiel, S.K. Steinman, J. Tanabe, D. Norman, W. Jagust, J.H. Kramer, J.A. Mastrianni, G. Fein and M.W. Weiner. Changes of Hippocampal N-Acetyl Aspartate and Volume in Alzheimer’s Disease: A Proton MR Spectroscopic Imaging and MRI Study. Neurology 1997; 49: 1513-21.
  8. Deicken RF, Zhou L, Schuff N, Weiner MW. Proton magnetic resonance spectroscopy of the anterior cingulate region in schizophrenia. Schizophrenia Research 1997 Oct 17;27(1):65-71.
  9. N. Schuff, D. Amend, D.J. Meyerhoff, J. Tanabe, D. Norman, G. Fein and M.W. Weiner. Quantitative Proton Magnetic Resonance Spectroscopic Imaging of Fronto-Parietal Brain in Alzheimer’s Disease. Radiology 1998 Apr;207(1):91-102.
  10. Deicken RF, Zhou L, Schuff N, Fein G, Weiner MW. Hippocampal neuronal dysfunction in schizophrenia as measured by proton magnetic resonance spectroscopy. Biol Psychiatry 1998 Apr 1;43(7):483-488.
  11. Rooney, W., Miller, RG. Gelinas, DF., Schuff, N., Maudsley, A.A., and Weiner M.W. Decreased motor cortex N-acetylaspartate in Amyotrophic Lateral Sclerosis. Neurology 1998, Jun, 50(6):1800-5.
  12. Norbert Schuff, Peter Vermathen, Andrew A. Maudsley, and Michael W. Wiener, Proton Magnetic Resonance Spectroscopic Imaging in Neurodegenerative Diseases, Current Science, 1998, Vol 76 (6); 800-807.
  13. Kwan LY, Reed BR, Eberling JL, Schuff N, Tanabe JD, Norman D, Weiner MW, and Jagust W.; Effects of Subcortical Cerebral Infraction on Cortical Glucose Metabolism and Cognitive Function. Archives of Neurology 1998, Vol (56); 809-14.
  14. Tanabe J, Ezekiel F, Jagust WJ, Reed BR, Norman D, Schuff N, Weiner MW, Fein G. Magnetization transfer ratio of white matter singal hyperintensities is reduced in subjects with lacunar infarction; American Journal of Neuroradiology 1999; 20:839-44.
  15. N. Schuff, D. Amend, R. Knowlton, J. Tanabe, D. Norman, G. Fein and M.W. Weiner. Age-related Metabolite Changes and Volume loss in Hippocampus by Proton MR Spectroscopic Imaging and MRI. Neurobiology of Aging 1999:20(3); 279-285.
  16. D. J. Meyerhoff, C. Bloomer, N. Schuff , F. Ezekiel, D. Norman, W. Clark, M.W. Weiner, and G. Fein. Cortical metabolite alterations in recently abstinent cocaine and cocaine/alcohol dependent subjects by proton magnetic resonance spectroscopic imaging. Addiction Biology, 1999; 4: 405-419.

2000
  1. Joseph O'Neill, Jamie Lynn Eberling, Norbert Schuff, Gabriel Soto, Frank Ezekiel, Gregory Klein, William Jagust, Michael Weiner; Method to Correlate 1H MRSI and 18FDG-PET Measurements. Magnetic Resonance in Medicine, 2000, 43:2; 244-25.
  2. AA. Capizzano, N. Schuff, D. Amend, JL.Tanabe, D. Norman, W.Jagust, AA. Maudsley, G. Fein, MW.Weiner. Subcortical ischemic vascular dementia: Role of quantitative MRI and 1HMRSI in assessment and diagnosis. American Journal of Neuroradiology, 2000, 21:621-630.
  3. Deicken RF, Johnson C, Eliaz Y, Schuff N. Reduced concentrations of thalamic N-acetylaspartate in male patients with schizophrenia. American Journal of Psychiatry, 2000:157; 644-647.
  4. Fein G, Di Sclafani V, Tanabe J, Cardenas V, Weiner MW, Jagust WJ, Reed BR, Norman D, Schuff N, Kusdra L, Greenfield T, and Chui H; Dementia in Subcortical Ischemic Vascular Disease Is Associated With Brain Atrophy, But Not With the Number, Location, or Volume of Lacunes; Neurology; 2000:55:1626-35.
  5. B.J. Soher, P. Vermathen, N. Schuff, D. Wiedermann, D.J. Meyerhoff, M.W Weiner, and A.A. Maudsley; Short TE in vivo 1H MR Spectroscopic Imaging at 1.5 T: Acquisition and Automated Spectral Analysis; Magnetic Resonance Imaging; 2000; 18(9); 1159-65.

2001
  1. N. Schuff, W. Rooney, D. Amend, D.F. Gelinas, D.L. Amend, A.A. Maudsley, and M.W. Weiner. Reanalysis of 1H MRSI in Amyotrophic Lateral Sclerosis; Magnetic Resonance in Medicine; 2001; 45:513-16.
  2. N. Schuff, F. Ezekiel, A. Gamst, D. Amend, A, Capizzano, AA. Maudsley, and M.W. Weiner. Region and Tissue Differences in Normally Aged Brain using Multislice 1H Magnetic Resonance Spectroscopic Imaging; Magnetic Resonance in Medicin; 2001; 45:899-907.
  3. Antao Du, Norbert Schuff, Diane Amend, Mikko P. Laakso, Yuan-Yu Hsu, William J. Jagust, Kristine. Yaffe, Joel H. Kramer, David Norman, Michael W. Weiner: MRI of Entorhinal Cortex and Hippocampus in Mild Cognitive Impairment and Alzheimer's Disease; Journal of Neurology, Neurosurgery, and Psychiatry; 2001;71:441-47.
  4. Wiedermann D, Schuff N, Matson GB, Soher BJ, Du AT, Maudsley AA, Weiner MW. Short echo time multislice proton magnetic resonance spectroscopic imaging in human brain: metabolite distributions and reliability. Magn Reson Imaging. 2001 Oct;19(8):1073-80.
  5. Deicken, RF, Eliaz Y, Feiwell R, Schuff N. Increased thalamic N-acetylaspartate in male patients with familial bipolar I disorder. Psychiatry Research: Neuroimaging Section106 (2001):35-45.
  6. Deicken RF, Feiwell R, Schuff N, Soher B. Evidence for altered cerebellar vermis neuronal integrity in schizophrenia. Psychiatry Res. 2001 Oct 1;107(3):125-34.
  7. Schuff N, Neylan TC, Lenoci MA, Du AT, Weiss DS, Marmar CR, Weiner MW. Decreased hippocampal N-acetylaspartate in the absence of atrophy in posttraumatic stress disorder. Biol Psychiatry. 2001 Dec 15;50(12):952-9.
  8. Mungas D, Jagust WJ, Reed BR, Kramer JH, Weiner MW, Schuff N, Norman D, Mack WJ, Willis L, Chui HC. MRI predictors of cognition in subcortical ischemic vascular disease and Alzheimer's disease. Neurology. 2001;57(12):2229-35.

2002
  1. Suhy J, Miller RG, Rule R, Schuff N, Licht J, Dronsky V, Gelinas D, Maudsley AA, Weiner MW. Early detection and longitudinal changes in amyotrophic lateral sclerosis by (1)H MRSI. Neurology. 2002;58(5):773-9.
  2. Rosen HJ, Kramer JH, Gorno-Tempini ML, Schuff N, Weiner M, Miller BL. Patterns of cerebral atrophy in primary progressive aphasia. Am J Geriatr Psychiatry. 2002;10(1):89-97.
  3. Rosen HJ, Gorno-Tempini ML, Goldman WP, Perry RJ, Schuff N, Weiner M, Feiwell R, Kramer JH, Miller BL. Patterns of brain atrophy in frontotemporal dementia and semantic dementia. Neurology. 2002; 58(2):198-208.
  4. N. Schuff; A.A. Capizzano; A.T. Du; D.L. Amend; J. O’Neill; D. Norman; W. Jagust; B. Miller; O.M. Wolkowitz; K. Yaffe; and M.W. Weiner; Selective Reduction of N-acetylaspartate in Hippocampus and Parietal Gray Matter in AD. Neurology 2002;58(6):928-35.
  5. Hsu YY, Schuff N, Amend DL, Du AT, Norman D, Chui HC, Jagust WJ, Weiner MW. Quantitative Magnetic Resonance Imaging Differences Between Alzheimer Disease With and Without Subcortical Lacunes; Alzheimer Dis Assoc Disord. 2002; 16(2):58-64.
  6. A.T. Du, N. Schuff, M.P. Laakso, PhD; X.P. Zhu, W.J. Jagust; K. Yaffe, J.H. Kramer, B.L. Miller, B.R. Reed, D. Norman, H.C. Chui, and M.W. Weiner: Effects of Subcortical Ischemic Vascular Dementia and AD on Entorhinal Cortex and Hippocampus. Neurology 2002;58:1635–1641.
  7. AA Capizzano, P Vermathen, KD Laxer, GB Matson, AA Maudsley, B Soher, N Schuff and MW Weiner; Multisection 1H MR Spectroscopy in Mesial Temporal Lobe Epilepsy. Am J Neuroradiol 2002 23: 1359-1368.
  8. Yuan-Yu Hsu, Norbert Schuff, An-Tao Du, Dawn Hardin, Xiaoping Zhu, Kevin Mark, and Michael W. Weiner: Automated Hippocampal MR Volumetry in Alzheimer Disease. Journal Magnetic Resonance Imaging 2002; 16:305-310.
  9. Joseph O'Neill, Norbert Schuff, William J. Marks, Robert Feiwell, and Michael W. Weiner Proton Magnetic Resonance Spectroscopy and Volumetric MRI of the Substantia nigra, Basal Ganglia, and Association and Motor Cortices in Idiopathic Parkinson's Disease; Mov Disord 2002 17(5):917-27.
  10. Howard J. Rosen, Richard J. Perry, Jennifer Murphy, Joel H. Kramer, Paula Mychack, Norbert Schuff, Michael Weiner, Robert W. Levenson, Bruce L. Miller. Emotion comprehension in the temporal variant of frontotemporal dementia. Brain 2002; 125(Pt 10):2286-95.
  11. Dan Mungas, Bruce R. Reed, William J. Jagust, Charles DeCarli, Wendy J. Mack, Joel H. Kramer, Michael W. Weiner, Norbert Schuff, Helena C. Chui: Volumetric MRI Predicts Rate of Cognitive Decline related to AD and Vascular Disease. Neurology 2002;59(6):867-73.

2003
  1. Geon-Ho Jahng, Xiao-Ping Zhu, Michael W Weiner, Norbert Schuff: Novel Multislice Perfusion Tagging Method Using Double Inversion with Proximal Labeling of Both Tagged and Control Images: DIPLOMA. Magnetic Resonance in Medicine; Magn Reson Med 2003; 49(2):307-14.
  2. VA Cardenas, AT Du, D Hardin, F Ezekiel, P Weber, WJ Jagust, HC Chui, N Schuff, MW Weiner, Comparison of methods for measuring longitudinal brain change in MCI and Dementia. Neurobiol Aging 2003 Jul-Aug; 24(4):537-44.
  3. A.T. Du, N. Schuff, X.P. Zhu, W.J. Jagust, B.L. Miller, B.R. Reed, J.H. Kramer, K. Yaffe, H.C. Chui, M.W. Weiner. Atrophy Rates of Entorhinal Cortex in AD and Normal Aging. Neurology 2003 Feb 11;60(3):481-6.
  4. Thomas C. Neylan, Norbert Schuff, Maryanne A. Lenoci, Rachel Yehuda, Michael W. Weiner, and Charles R. Marmar. Cortisol Levels are Correlated with Hippocampal N-Acetylasparte. Biol Psychiatry. 2003;54(10):1118-21.
  5. Peter Vermathen, Kenneth D. Laxer, Norbert Schuff, Gerald B. Matson, and Michael W. Weiner; Evidence for Neuronal Injury Outside Mesial Temporal Lobe in Temporal Lobe Epilepsy: NAA Reductions Detected by Multislice Proton MRSI. Radiology 2003 Jan;226(1):195-202.
  6. N. Schuff, A.A. Capizzano, A.T. Du, D.L. Amend, J. O'Neill, D. Norman, J W. Jagust, H. Chui, Kramer, B. Miller, K. Yaffe, and M.W. Weiner. Different Patterns of N-acetylaspartate Loss in Ischemic Vascular Dementia and AD. Neurology. 2003 Aug 12;61(3):358-364.
  7. Boxer AL, Rankin KP, Miller BL, Schuff N, Weiner M, Gorno-Tempini ML, Rosen HJ. Cinguloparietal atrophy distinguishes Alzheimer's disease from semantic dementia. Arch Neurol. 2003 Jul;60(7):949-56.
  8. Zhu XP, Du AT, Zhang GH, Soher B, Maudsley AA, Weiner MW, Schuff N. Magnetic Resonance Imaging Reconstruction with Deformable Shape-Intensity Models. Magn Reson Med. 2003 Sep;50(3):474-82.
  9. A.L. Boxer, JL. Kramer, N. Schuff, M.W. Weiner, B.L. Miller. Focal right inferotemporal atrophy in AD with disproportionate visual constructive impairment. Neurology. 2003; 61(11): 1485-91.
  10. TC. Neylan, M. Lenoci, , J. Rothlind, TJ. Metzler, N. Schuff, K. Franklin, DS. Weiss, MW. Weiner, and CR. Marmar. Attention, Learning, and Memory in Posttraumatic Stress Disorder. Journal of Traumatic Stress. Biol Psychiatry. 2003; 54(10): 1118-21.

2004
  1. A.T. Du, N. Schuff, J.H. Kramer, S. Ganzer, X.P. Zhu, W.J. Jagust, B.L. Miller, BR Reed, D. Mungas, K. Yaffe, H.C. Chui, M.W. Weiner. Higher Atrophy Rate of Entorhinal Cortex than Hippocampus in AD. Neurology. 2004 Feb 10;62(3):422-7.
  2. C.Studholme, V. Cardenas, R. Blumenfeld, N. Schuff, H.J. Rosen, B. Miller, M. Weiner, "A Deformation Tensor Morphometry Study of Semantic Dementia with Quantitative Validation", NeuroImage, Vol 21, pp 1387-1398, April 2004.
  3. Kramer JH, Mungas D, Reed BR, Schuff N, Weiner MW, Miller BL, Chui HC. Forgetting in dementia with and without subcortical lacunes. Clin Neuropsychol. 2004 Feb;18(1):32-40.
  4. Rankin KP, Rosen HJ, Kramer JH, Schauer GF, Weiner MW, Schuff N, Miller BL. Right and left medial orbitofrontal volumes show an opposite relationship to agreeableness in FTD. Dement Geriatr Cogn Disord. 2004;17(4):328-32.
  5. Joel H. Kramer, Norbert Schuff, Bruce R. Reed, Dan Mungas, Antao Du, Howard J. Rosen, William J. Jagust, Bruce L. Miller, Michael W. Weiner, and Helena C. Chui.. Hippocampal Volume and Retention in Alzheimer’s Disease. J Int Neuropsychol Soc. 2004 Jul;10(4):639-43
  6. L. G. Kaiser, N. Schuff, and M.W. Weiner, Detection of Scyllo-Inositol in Normal Human Brain: 1H magnetic resonance spectroscopy study at 4 Tesla. NMR. Biomed. 2004 Oct 4;18(1):51-55.
  7. F Ezekiel, LL Chao, J Kornak, AT Du, VA Cardenas, D Sacrey, WJ Jagust, HC Chui, N Schuff, MW Weiner. Comparisons between boundary shift integral, manual entorhinal cortex and automatic hippocampal volume changes over time in normal aging and Alzheimer’s disease. Alzheimer Dis Assoc Disord. 2004 Oct;18(4):196-201.
  8. R.R. Rule, J. Suhy, N.Schuff, D.F. Gelinas, R.G. Miller, and M.W. Weiner. Reduced NAA in motor and non-motor brain regions in Amyotrophic Lateral Sclerosis: A cross sectional and longitudinal study. Amyotroph Lateral Scler Other Motor Neuron Disord. 2004 Sep;5(3):141-9.

2005
  1. An-Tao Du, Norbert Schuff, Linda L. Chao, Frank Ezekiel, John Kornak, William J. Jagust, Joel H. Kramer, Bruce R. Reed, Bruce L. Miller, Helena C. Chui, Michael W. Weiner. White matter lesions impact the cortex more than the entorhinal cortex and hippocampus. Neurobiology of Aging 2005;26(4):553-559..
  2. Geon-Ho Jahng, Enmin Song, Xiao-Ping Zhu, Gerald B Matson, Michael W Weiner, Norbert Schuff. Global and Regional Reliability and Reproducibility of Pulsed Arterial Spin Labeled Perfusion MRI in the Human Brain. Radiology 2005; 234:909-916.
  3. L. G. Kaiser, N. Schuff, N. Cashdollar, and M.W. Weiner. Glutamate and glutamine variability in normal human brain: in vivo 1H MR spectroscopy study at 4 Tesla. Neurobiol Aging. 2005 May;26(5):665-72.
  4. Nathan Johnson, Geonho Jahng, Xiaoping Zhu, Michael Weiner, and Norbert Schuff. Pattern of Cerebral Hypoperfusion in Alzheimer’s Disease and Mild Cognitive Impairment Measured With Arterial Spin Labeled MRI. Radiology 2005;234: 851-859.
  5. L.L. Chao, N. Schuff, J.H. Kramer, A.T. Du, A.A. Capizzano, J. O'Neill, O.M. Wolkowitz, W.J. Jagust, H.C. Chui, B.L. Miller, K. Yaffe, and M.W. Weiner. Selective Reduction of N-acetylaspartate in the Medial Temporal Lobes of Cognitively Impaired but Non-Demented Elderly Adults. Neurology 2005 Jan 25;64(2):282-9.
  6. Ka-Loh Li, Xiaoping Zhu, Nola Hylton, Geonho Jahng, Michael M. Weiner, and Norbert Schuff. A Four-Phase-Single-Capillary Stepwise Model for Kinetics in Arterial Spin Labeling. Magnetic Resonance in Medicine. 2005 Mar;53(3):511-89.
  7. Karl Young, Yue Chen , John Kornak, Gerald B. Matson, and Norbert Schuff. Summarizing Complexity in High Dimensions. Physical Review Letters. 94; 098701 (2005).
  8. Geon-Ho Jahng, Lara Stables, Andreas Ebel, Gerald Matson, Dieter J Meyerhoff, Michael W Weiner, and Norbert Schuff. Sensitive and Fast T1 Mapping Based on Two Inversion Recovery Images and a Reference Image. Medical Physics 2005:.32 (6):1524-28.
  9. Mungas D, Harvey D, Reed BR, Jagust WJ, DeCarli C, Beckett L, Laurel Beckett, Wendy J. Mack, Joel H. Kramer, Michael W. Weiner, Norbert Schuff, Helena C. Chui. Longitudinal volumetric MRI change and rate of cognitive decline. Neurology 2005; 65(4):565-571.
  10. Ebel A, Maudsley AA, Weiner MW, Schuff N. Achieving sufficient spectral bandwidth for volumetric 1H echo-planar spectroscopic imaging at 4 Tesla. Magn Reson Med 2005; 54(3):697-701.

2006
  1. Du AT, Schuff N, Chao LL, Kornak J, Jagust WJ, Kramer JH, Bruce R. Reed, Bruce L. Miller, David Norman, Helena C. Chui, Michael W. Weiner. Age effects on atrophy rates of entorhinal cortex and hippocampus. Neurobiol Aging. 2006 ;27(5):733-40.
  2. Joel H. Kramer, Howard Rosen, An-Tao Du, Norbert Schuff, Caroline Odell, Dean C. Delis, Michael W. Weiner, and Bruce L. Miller. Dissociation in Hippocampal and Frontal Contributions to Episodic Memory Performance. Neuropsychology. 2005 Nov; 19(6):799-805.
  3. Satoru Hayasaka, An-Tao Du, Audrey Duarte, John Kornak, Geon-Ho Jahng, Michael W Weiner, and Norbert Schuff. A Non-Parametric Approach for Co-Analysis of Multi-Modal Brain Imaging Data: Application to Alzheimer’s Disease. Neuroimage. 2006; 30(3):768-79.
  4. Leow AD, Klunder AD, Jack CR, Toga AW, Dale AM, Bernstein MA, Britson PJ, Gunter JL, Ward CP, Whitwell JL, Borowski B, Fleisher A, Fox NC, Harvey D, Kornak J, Schuff N, Studholme C, Alexander GE, Weiner MW, Thompson PM; Longitudinal Stability of MRI for Mapping Brain Change using Tensor-Based Morphometry. Neuroimage. 2006; 31(2):627-40.
  5. Zhu XP, Weiner WM, and Schuff N. Analysis of Short Echotime 1H MRSI in Human Brain by Principle Components and Regional Mean Spectra. Magn Reson Med. 2006; 55(3):706-11.
  6. Xiaoping Zhu, Norbert Schuff, John Kornak, Brian Soher, Kristine Yaffe, Joel H. Kramer, Frank Ezekiel, Bruce L. Miller, William J. Jagust, Michael W. Weiner. Effects of Alzheimer Disease on Fronto-parietal Brain N-acetyl Aspartate and Myo-Inositol Using Magnetic Resonance Spectroscopic Imaging. Alzheimer Dis Assoc Disord. 2006; 20(2):77-85.
  7. A.A. Maudsley, A. Darkazanli, J.R. Alger, L.O. Hall, N. Schuff, C. Studholme, A. Frew, D. Goldgof, R. Pagare, F. Rousseau, K. Sivasankaran, B.J. Soher, P. Weber, K. Young, Y. Yu, and G. Yuhua. Comprehensive Processing, Display, and Analysis for in-vivo MR Spectroscopic Imaging. NMR in Biomedicine 2006; 19: 492-503.
  8. An-Tao Du, Geon-Ho Jahng, Satoru Hayasaka, Joel H. Kramer, Howie Rosen, Bruce L. Miller, Michael W. Weiner, Norbert Schuff. Different Patterns of Hypoperfusion in Frontotemporal Dementia and Alzheimer’s Disease by Arterial Spin Labeling MRI. Neurology. 2006; 67(7):1215-20.
  9. Mueller S.G., Stables L., Du A.T., Schuff N, Truran D., Cashdollar N, Weiner M.W. Measurement of Hippocampal Subfields and Age-related Changes with High Resolution MRI at 4 Tesla. NMR Biomed. 2006; 19(6):655-68.
  10. Audrey Duarte, Satoru Hayasaka, Antao Du, Norbert Schuff, Geon-Ho Jahng, Joel Kramer , Bruce Miller, Michael Weiner Volumetric correlates of executive functioning and episodic memory in healthy aging, Mild Cognitive Impairment and Alzheimer’s Disease. Neurosci Lett. 2006 ;406(1-2):60-5.
  11. Mueller SG, Schuff N, Weiner MW. Evaluation of treatment effects in Alzheimer's and other neurodegenerative diseases by MRI and MRS. NMR Biomed. 2006; 19(6):655-68.

2007
  1. Y. Zhang, N. Schuff, GH. Jahng, W. Bayne, S. Mori, L. Schad, S. Mueller, J Kramer, K. Yaffe, H Chui, WJ. Jagust, BL. Miller, MW. Weiner. Abnormalities of Cingulum Fibers on Diffusion Tensor Imaging in Mild Cognitive Impairment and Alzheimer’s Disease. Neurology. 2007; 68(1):13-9.
  2. Ashish Raj, Gurneet Singh, Ramin Zahib, Bryan Kessler, Yi Wang, Norbert Schuff, Michael W. Weiner. Bayesian Parallel Imaging with Edge-Preserving Priors. Magn Reson Med. 2007; 57(1):8-21.
  3. S.G. Mueller, K.D. Laxer, C. Paul, N Cashdollar, N. Schuff, M.W. Weiner; Voxel-based Relaxation Ratio Measurements in Temporal Lobe Epilepsy (TLE) with and without Mesial Temporal Sclerosis. Epilepsia. 2007 Feb;48(2):220-8.
  4. Andreas Ebel, Andrew A. Maudsley, Michael W. Weiner, and Norbert Schuff; Correction of Local B0-Shifts for 3D EPSI of Human Brain at 1.5 and 4 Tesla. Magnetic Resonance Imaging 2007; 25:377-380
  5. Xiaoping Zhu, Andreas Ebel, Jim X Hi, Norbert Schuff. Spectral Phase Corrected GRAPPA Reconstruction of Three-Dimensional Echo Planar Spectroscopic Imaging (3D-EPSI. Magn Reson Med. 2007; 57(5):815-20.
  6. A.T. Du, N. Schuff, J.H. Kramer, H.J. Rosen, M.L. Gorno-Tempini, K.P. Rankin, B.L. Miller, M.W. Weiner. Different patterns of cortical thinning in Alzheimer disease and frontotemporal dementia. Brain. 2007; 130(Pt 4):1159-66.
  7. l.l. Chao, N.Schuff, E.M. Clevenger, S.G. Mueller, H. J. Rosen, M.L. Gorno-Tempini, J. H. Kramer, B.L. Miller, and M.W. Weiner. Patterns of white matter atrophy in frontotemporal lobar degeneration. Arch Neurol. 2007 Nov;64(11):1619-24.
  8. Mathews Jacobs, Xiaoping Zhu, Thimothy Deller, Andreas Ebel, Norbert Schuff, Zhi-Pei Liang. Improved Model-Based Magnetic Resonance Imaging. IEEE Trans Med Imaging. 2007 Oct;26(10):1305-18.
  9. Andreas Ebel and Norbert Schuff. Accelerated 3D Echo-Planar Spectroscopic Imaging at 4 Tesla Using Modified Blipped Phase-Encoding. Magn Reson Med. 2007 Nov;58(5):1061-6
  10. Geon-Ho Jahng, Michael W Weiner, and Norbert Schuff. Improved Arterial Spin Labeling: Applications for Measurements of Cerebral Blood Flow in Human Brain at High Magnetic Field MRI. Med Phys. 2007 Nov;34(11):4519-25.
  11. Stathis Hadjidemetriou, Colin Studholme, Susanne Mueller, Michael Weiner, and Norbert Schuff. Restoration of MRI Data for Field Nonuniformities using High Order Neighborhood Statistics. Proc Soc Photo Opt Instrum Eng. 2007 Mar 5;6512-21.
  12. Hadjidemetriou S, Studholme C, Mueller S, Weiner M, Schuff N. Restoration of MRI Data for Field Nonuniformities using High Order Neighborhood Statistics. Proc Soc Photo Opt Instrum Eng. 2007 Mar 5;6512:65121
2008
  1. Catherine L. Carey, Joel H. Kramer, S. Andrew Josephson, Dan Mungas, Bruce R. Reed, Norbert Schuff, Michael W. Weiner, Helena C. Chui. Subcortical Lacunes are Associated with Executive Dysfunction in Cognitively Normal Elderly. Stroke. 2008 Feb;39(2):397-402.
  2. Karl Young and Norbert Schuff. Measuring Structural Complexity in Medical Images. Neuroimage. 2008 Feb 15;39(4):1721-30.
  3. Norbert Schuff, Thomas C. Neylan, Sabrina Fox-Bosetti, Maryanne A. Lenoci, Kristin W. Samuelson, Colin Studholme, John Kornak, Charles R. Marmar, Michael W. Weiner. Reduced N-Acetylaspartate of Hippocampus and Anterior Cingulate in Absence of Brain Atrophy in Posttraumatic Stress Disorder. Psychiatric Research Neuroimaging 2008 Feb 28;162(2):147-57.
  4. Jack CR Jr, Bernstein MA, Fox NC, Thompson P, Alexander G, Harvey D, Borowski B, Britson PJ, L Whitwell J, Ward C, Dale AM, Felmlee JP, Gunter JL, Hill DL, Killiany R, Schuff N, Fox-Bosetti S, Lin C, Studholme C, Decarli CS; Gunnar Krueger, Ward HA, Metzger GJ, Scott KT, Mallozzi R, Blezek D, Levy J, Debbins JP, Fleisher AS, Albert M, Green R, Bartzokis G, Glover G, Mugler J, Weiner MW; ADNI Study. The Alzheimer's disease neuroimaging initiative (ADNI): MRI methods. J Magn Reson Imaging. 2008.
  5. WJ. Jagust, L. Zheng, D.J. Harvey, W.J. Mack, H.V. Vinters, M.W. Weiner, W.G. Ellis, C. Zarow, D. Mungas, B.R. Reed, JH. Kramer, N. Schuff, C. DeCarli, and H.C. Chui. Neuropathological Basis of MR Images in Aging and Dementia. Ann Neurol. 2008 Jan;63(1):72-80.
  6. Richard Boyes, Jeff Gunter, Chris Frost, Andrew Janke, Thomas Yeatman, Derek Hill, Anders Dale, Matt A. Bernstein, Paul M. Thomson, Michael W. Weiner, Norbert Schuff, Gene E. Alexander, Ronald J. Killiany, Charles DeCarli, Marylin Albert, Nick Fox, Clifford Jack. Quantitative Analysis of Image Intensity Restoration using N3 on 3 Tesla Scanners with Multichannel Phased Array coils. Neuroimage. 2008 Feb 15;39(4):1752-1762.
  7. N. Schuff: The Value of High Field MRI for Studies of Parkinson’s disease. (Journal of Movement Disorders, in press).
  8. N. Schuff and X.P. Zhu. Imaging of Mild Cognitive Impairment and Early Dementia. (British Journal of Radiology in press).